{"id":1948,"date":"2017-09-05T14:34:50","date_gmt":"2017-09-05T14:34:50","guid":{"rendered":"https:\/\/www.wanimo.com\/veterinairev2\/index.php\/2017\/09\/05\/la-mutation-du-gene-mdr1-chez-le-chien\/"},"modified":"2025-04-01T08:32:13","modified_gmt":"2025-04-01T08:32:13","slug":"la-mutation-du-gene-mdr1-chez-le-chien","status":"publish","type":"post","link":"https:\/\/conseils.wanimo.com\/veterinaire\/medecine-generale-du-chien\/la-mutation-du-gene-mdr1-chez-le-chien.html","title":{"rendered":"La mutation du g\u00e8ne MDR1 chez le chien"},"content":{"rendered":"

Chez certaines races (Colley par exemple), il existe une mutation g\u00e9n\u00e9tique rendant les chiens sensibles \u00e0 certains m\u00e9dicaments et notamment \u00e0 des traitements antiparasitaires. Il est conseill\u00e9 de d\u00e9pister les chiens appartenant \u00e0 ces races pour voir s’ils sont porteurs de cette mutation.
\n<\/strong><\/p>\n

<\/p>\n

\u00a0<\/strong><\/p>\n

Qu\u2019est ce que la mutation du g\u00e8ne MDR1\u00a0?<\/h2>\n

La mutation du g\u00e8ne MDR1 touche principalement les chiens de race Colley. Elle est aussi rencontr\u00e9e chez d\u2019autres chiens de berger\u00a0: Berger des Shetland, Berger Australien, Border Collie, Berger Blanc Suisse, etc\u2026<\/p>\n

Il s\u2019agit d\u2019une mutation touchant le g\u00e8ne MDR1, MDR signifiant multir\u00e9sistance aux mol\u00e9cules. Le g\u00e8ne MDR1 code pour une prot\u00e9ine situ\u00e9e au niveau de la barri\u00e8re h\u00e9mato-m\u00e9ning\u00e9e (barri\u00e8re situ\u00e9e dans le cerveau et s\u00e9parant la circulation sanguine du syst\u00e8me nerveux). Lorsque le g\u00e8ne MDR1 est mut\u00e9, cette prot\u00e9ine est non fonctionnelle voire absente et certains m\u00e9dicaments vont s\u2019accumuler au niveau du syst\u00e8me nerveux.<\/p>\n

Dans les cellules, les chromosomes sont associ\u00e9s par paire, il y a donc deux g\u00e8nes MDR1 chez un individu.<\/p>\n

Si un chien pr\u00e9sente les deux g\u00e8nes MDR1 mut\u00e9s, alors on dit qu\u2019il est homozygote mut\u00e9 (-\/-). Ce sont les chiens les plus sensibles aux m\u00e9dicaments et il faut faire tr\u00e8s attention aux m\u00e9dicaments utilis\u00e9s.<\/p>\n

Si un chien pr\u00e9sente un g\u00e8ne mut\u00e9, alors il est h\u00e9t\u00e9rozygote (+\/-). Il faut \u00e9galement \u00eatre prudent car ils peuvent pr\u00e9senter des sympt\u00f4mes suite \u00e0 la prise de m\u00e9dicaments mais ils sont g\u00e9n\u00e9ralement moins s\u00e9v\u00e8res que chez les homozygotes mut\u00e9s.<\/p>\n

Enfin, un chien qui ne pr\u00e9sente pas de mutation est dit homozygote sain (+\/+). Les chiens qui ne sont pas atteints tol\u00e8rent naturellement \u00ab\u00a0tous\u00a0\u00bb les m\u00e9dicaments.<\/p>\n

\u00a0<\/strong><\/p>\n

Quels sont les risques pour les chiens\u00a0?<\/h2>\n

Il existe de nombreux m\u00e9dicaments toxiques pour les chiens pr\u00e9sentant une mutation du g\u00e8ne MDR1. C\u2019est le cas des antiparasitaires appartenant \u00e0 la famille des avermectines (ivermectine, s\u00e9lamectine, etc\u2026) par exemple.<\/p>\n

Si les v\u00e9t\u00e9rinaires ne savent pas si l\u2019animal est homozygote mut\u00e9 ou h\u00e9t\u00e9rozygote mut\u00e9, ils \u00e9vitent g\u00e9n\u00e9ralement l\u2019utilisation des m\u00e9dicaments \u00e0 risque. Par contre, les propri\u00e9taires d\u2019animaux peuvent utiliser des antiparasitaires contre-indiqu\u00e9s, pratiquer de l\u2019auto-m\u00e9dication, etc\u2026<\/p>\n

Les signes cliniques apparaissent dans les 48 heures suivant l\u2019administration du m\u00e9dicament. On rencontre essentiellement des sympt\u00f4mes nerveux avec de l\u2019ataxie (perte d\u2019\u00e9quilibre), des tremblements, des convulsions, un coma\u2026Des sympt\u00f4mes oculaires et digestifs (ptyalisme, vomissements\u2026) peuvent aussi \u00eatre pr\u00e9sents.<\/p>\n

Il est conseill\u00e9 de consulter rapidement un v\u00e9t\u00e9rinaire pour la mise en place d\u2019un traitement adapt\u00e9. Le pronostic est r\u00e9serv\u00e9 : il s\u2019agit d\u2019une intoxication pouvant \u00eatre mortelle.<\/p>\n

Etant donn\u00e9 la gravit\u00e9 des sympt\u00f4mes, il est conseill\u00e9 de d\u00e9pister les chiens appartenant aux races pr\u00e9dispos\u00e9es. Un v\u00e9t\u00e9rinaire pourra r\u00e9aliser le pr\u00e9l\u00e8vement (\u00e9couvillon buccal) \u00e0 envoyer au laboratoire pour le d\u00e9pistage de l\u2019animal.<\/p>\n","protected":false},"excerpt":{"rendered":"

Chez certaines races (Colley par exemple), il existe une mutation g\u00e9n\u00e9tique rendant les chiens sensibles \u00e0 certains m\u00e9dicaments et notamment \u00e0 des traitements antiparasitaires. Il est conseill\u00e9 de d\u00e9pister les chiens appartenant \u00e0 ces races pour voir s’ils sont porteurs de cette mutation.<\/p>\n","protected":false},"author":1,"featured_media":1947,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[37],"tags":[],"yoast_head":"\nLa mutation du g\u00e8ne MDR1 chez le chien - WanimoV\u00e9to<\/title>\n<meta name=\"description\" content=\"Chez certaines races (Colley par exemple), il existe une mutation g\u00e9n\u00e9tique rendant les chiens sensibles \u00e0 certains m\u00e9dicaments et notamment \u00e0 des\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/conseils.wanimo.com\/veterinaire\/medecine-generale-du-chien\/la-mutation-du-gene-mdr1-chez-le-chien.html\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" 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certaines races (Colley par exemple), il existe une mutation g\u00e9n\u00e9tique rendant les chiens sensibles \u00e0 certains m\u00e9dicaments et notamment \u00e0 des traitements antiparasitaires. Il est conseill\u00e9 de d\u00e9pister les chiens appartenant \u00e0 ces races pour voir s’ils sont porteurs de cette mutation.","_links":{"self":[{"href":"https:\/\/conseils.wanimo.com\/veterinaire\/wp-json\/wp\/v2\/posts\/1948"}],"collection":[{"href":"https:\/\/conseils.wanimo.com\/veterinaire\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/conseils.wanimo.com\/veterinaire\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/conseils.wanimo.com\/veterinaire\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/conseils.wanimo.com\/veterinaire\/wp-json\/wp\/v2\/comments?post=1948"}],"version-history":[{"count":2,"href":"https:\/\/conseils.wanimo.com\/veterinaire\/wp-json\/wp\/v2\/posts\/1948\/revisions"}],"predecessor-version":[{"id":7182,"href":"https:\/\/conseils.wanimo.com\/veterinaire\/wp-json\/wp\/v2\/posts\/1948\/revisions\/7182"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/conseils.wanimo.com\/veterinaire\/wp-json\/wp\/v2\/media\/1947"}],"wp:attachment":[{"href":"https:\/\/conseils.wanimo.com\/veterinaire\/wp-json\/wp\/v2\/media?parent=1948"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/conseils.wanimo.com\/veterinaire\/wp-json\/wp\/v2\/categories?post=1948"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/conseils.wanimo.com\/veterinaire\/wp-json\/wp\/v2\/tags?post=1948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}